Table 2 General properties for scaffolds and challenges
From: Electrospun nanofibers for the fabrication of engineered vascular grafts
| General Properties Of Scaffolds | Challenges | References |
|---|---|---|
| Biocompatibility | • Non-controlling degradation of biodegradable polymers in vivo | [103, 104] |
| • The toxicity of products produced by the degradation of biocompatible polymers | ||
| • Low cell seeding efficiency | ||
| Mechanical Properties proper for tissue | • Scaffolding design with mechanical properties proportional to tissue | [29, 38] |
| • Mechanical integrity | ||
| • Protect cells against tensile and pressing forces | ||
| Biodegradability | • The completion of the tissue healing is dependent on the rate of biodegradation | [105, 106] |
| • At least toxicity and inflammation | ||
| • Transmit the tissue growth conduction signals and differentiation | ||
| • Cell migration | ||
| • Pore size and porosity proportional to the tissue | ||
| Porous interconnectivity | • At least toxicity and inflammation | [105, 106] |
| • Transmit the tissue growth conduction signals and differentiation | ||
| • Pore size and porosity proportional to the tissue | ||
| • The possibility of exchanging gases, nutrients and growth factors and waste materials | ||
| • Cell migration | ||
| Chemical surface and topography | • Cell-cell interactions and cell adhesion, controlling cell function | [91, 107] |