Table 1 Follicle-secreted factors and their functions, classified by secreting cell type
From: Follicle development as an orchestrated signaling network in a 3D organoid
| Oocyte-Secreted Factors | |
|---|---|
| BMP-15, GDF-9 | Promotes granulosa proliferation and theca layer development [13, 20,21,22,23,24, 27, 35, 55] |
| FGF-2, FGF-8 | Promotes granulosa cell proliferation and survival [37, 39,40,41,42, 44] |
| Granulosa Cell-Secreted Factors | |
| Activin, BMP-2, BMP-5 | Promote granulosa cell proliferation [29, 57,58,59,60] |
| MIF, EGF, FGF-8 | Promote theca layer development [17, 27, 55, 56] |
| FGF-2 | Promote theca layer angiogenesis [18, 76] |
| Aquaporin, Versican | Facilitate antrum development [53, 78, 80] |
| Theca Cell-Secreted Factors | |
| BMP-7 | Promotes granulosa cell proliferation [45] |
| FGF-7 | Promotes theca layer development [74] |