Table 4 Model variables and parameters
From: Design and engineering of a transmissible antiviral defense
| Notation | Description | Values |
|---|---|---|
| Variables | ||
| V | Density of vaccine (free particles) | |
| M | Density of helper virus (free particles) | |
| L | Density of lethal virus (free particles) | |
| H u | Density of uninfected cells | |
| H VS | Density of cells infected with vaccine but still sensitive to lethal virus | |
| H VR | Density of cells infected with vaccine and resistant to lethal virus | |
| H M | Density of cells infected with helper | |
| H VMS | Density of cells infected with vaccine and helper but still sensitive to lethal virus | |
| H VMR | Density of cells infected with vaccine and helper and resistant to lethal virus | |
| Functions | ||
| G | Density-adjusted growth factor for all cells [ =1−(H u +H M +H VS +H VR +H VMS +H VMR )/C] | |
| Parameters | ||
| k V | Adsorption rate of vaccine to uninfected cells (mL/min) | 5×10−9 |
| k M | Adsorption rate of helper virus to all cells that it infects (mL/min) | 5×10−9 |
| k L | Adsorption rate of lethal virus to all cells that it infects cells (mL/min) | 5×10−10 |
| r u | Intrinsic growth rate of uninfected cells (/min) | 0.033 |
| r V | Intrinsic growth rate of vaccine-infected cells (/min) | 0.033 |
| r M | Intrinsic growth rate of helper-infected cells (/min) | 0.03 |
| r VM | Intrinsic growth rate of cells infected with vaccine and helper (/min) | 0.025 |
| c | Rate of conversion to T5 resistance by vaccine-infected cells (/min) | 0.1, 0.001 |
| b M | Rate at which helper-infected cells produce helper (/min) | 0.5 |
| b VM | Rate at which vaccine-infected, helper-infected cells produce vaccine (/min) | 0.7 |
| b MV | Rate at which vaccine-infected, helper-infected cells produce helper (/min) | 0.006 |
| b L | Burst size of a cell infected with lethal virus | 200 |
| τ | Time after infection that a cell infected with the lethal virus dies (min) | 30 |
| C | Carrying capacity of environment | 1×109 |